Effect of sodium butyrate on the stimulation of casein gene expression by prolactin

FEBS Letters

Martel, Paule¹  Houdebine, Louis-Marie²  Teyssot, Bertrand² 

[1] Laboratoire des Sciences de la Consommation, France;Laboratoire de Physiologie de la Lactation, Institut National de la Recherche Agronomique, CNRZ, 78350 Jouy-en-Josas, France

关键词: Casein synthesis;    Casein mRNA;    Casein gene transcription;    Sodium butyrate;    Prolactin intracellular relay;   

DOI  :  10.1016/0014-5793(83)80874-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Sodium butyrate, but not isobutyrate, inhibits prolactin action on the induction of casein synthesis and casein mRNA accumulation in rabbit mammary explants. Sodium butyrate specifically prevents the generation of the prolactin relay which can be released from isolated membranes incubated with prolactin and which stimulates directly casein gene transcription when added to isolated mammary nuclei. This indicates that sodium butyrate exerts its inhibitory action essentially at the membrane level.

【 授权许可】

Unknown