Biosynthesis of 3β‐hydroxy‐5,7‐pregnadien‐20‐one by the horse fetal gonad

FEBS Letters

Allen, W.R.¹  Hodge, L.C.²  Tait, A.D.² 

[1] Thoroughbred Breeders' Association, Equine Fertility Unit, ARC Institute of Animal Physiology, Animal Research Station, 307 Huntington Rd., Cambridge, England;Departments of Medicine and Obstetrics and Gynaecology, University of Cambridge, Addenbrookes Hospital, Hills Rd., Cambridge, England

关键词: Equilin;    Biosynthesis;    Precursor;    Horse;    Fetal gonad;   

DOI  :  10.1016/0014-5793(83)80139-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The production of equilin and the other ring B-unsaturated estrogens by the pregnant mare is anomalous in that they are biosynthesised by a cholesterol-independent pathway. Fetal horse gonads were incubated with tritiated sodium acetate and radiochemically pure 3β-hydroxy-5,7-pregnadien-20-one and 3β-hydroxy-5,7-androstadien-17-one were isolated. A fetal gonad-placental system is proposed for equilin production, 3β-hydroxy-5,7-pregnadien-20-one being a precursor for 3β-hydroxy-5,7-androstadien-17-one in the fetal gonad and the latter being the precursor of equilin in the placenta. The nature of the possible precursor of 3β-hydroxy-5,7-pregnadien-20-one is discussed.

【 授权许可】

Unknown