The effect of N 6‐phenylisopropyladenosine on the regulation of fat cell hexose transport, glucose oxidation and fatty acid release by insulin and catecholamines

FEBS Letters

Strada, Samuel J.²  Stouffer, John E.¹  Thompson, W.Joseph²  Souness, John E.² 

[1] Marss McLean Department of Biochemistry, Baylor College of Medicine, Texas Medical Center, Houston, TX 77030, USA;Department of Pharmacology, The University of Texas Medical School at Houston, Texas Medical Center, Houston, TX 77025, USA

关键词: N6-phenylisopropyladenosine;    Fat cell metabolism;    Insulin;    Catecholamine;    Modulation;   

DOI  :  10.1016/0014-5793(83)80127-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

N ⁶-Phenylisopropyladenosine was employed in the absence of endogenous adenosine to explore the influence exerted by the R-site over the antagonistic interaction of insulin and catecholamines on several parameters of fat cell metabolism. When no hormones were present, N ⁶-phenylisopropyladenosine had little or no effect; however, the nucleoside potentiated insulin inhibition of catecholamine-stimulated events, such as lipolysis, and conversely, diminished or blocked catecholamine inhibition of insulin-stimulated processes, such as 2-deoxyglucose uptake, glucose oxidation and esterification, even under conditions where N ⁶-phenylisopropyladenosine, alone, was ineffective in reversing catecholamine actions.

【 授权许可】

Unknown