Formation of the COOH‐terminal amide group of thyrotropin‐releasing‐factor

FEBS Letters

Husain, Intisar¹  Tate, Suresh S.¹ 

[1]Department of Biochemistry, Cornell University Medical College, New York, NY 10021, USA

关键词: Thyroliberin;    Carboxy terminal amide;    Amidation;    Pituitary;   

DOI  :  10.1016/0014-5793(83)80395-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The precursors of peptide hormones that possess a COOH-terminal α-amide group contain a glycine residue following the amino acid which is amidated in the hormone. 〈Glu—His—Pro—Gly was synthesized as a putative precursor of thyroliberin. Bovine pituitary neurosecretory granules were shown to contain an amide group-forming activity associated with an M _r of about 62000 protein(s) which converts the tetrapeptide to thyroliberin.

【 授权许可】

Unknown