Possible physiological role of epidermal growth factor in the development of the mouse mammary gland during pregnancy

FEBS Letters

Taketani, Yuji¹  Oka, Takami¹ 

[1] Laboratory of Biochemistry and Metabolism, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20205, USA

关键词: Epidermal growth factor;    Mammary gland;    Growth;    Differentiation;    Milk protein synthesis;    Pregnancy;   

DOI  :  10.1016/0014-5793(83)80391-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Epidermal growth factor stimulated cell proliferation in a primary mammary epithelial cell culture derived from mice at different stages of pregnancy. Moreover, the peptide hormone inhibited casein production induced by the synergistic actions of insulin, cortisol and prolactin. The inhibitory effect of epidermal growth factor was influenced by the gestational stages of the mammary gland. These effects of epidermal growth factor were exerted at physiological concentrations. The dual actions of epidermal growth factor on mammary cells implicate its participation in regulation of the growth and differentiation of the mammary gland during pregnancy.

【 授权许可】

Unknown