Induction of maturation of rat follicle‐enclosed oocyte by forskolin

FEBS Letters

Sherizly, I.¹  Dekel, N.¹ 

[1] The Weizmann Institute of Science, Department of Hormone Research, Rehovot 76100, Israel

关键词: Oocyte maturation;    cAMP;    Forskolin;    Ovarian follicle;    Germinal vesicle;    GV;    germinal vesicle;    GVB;    GV breakdown;   

DOI  :  10.1016/0014-5793(83)80362-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The diterpene forskolin, which was found to be a potent and reversible activator of adenylate cyclase in intact tissues as well as in broken cell preparations, was employed to investigate the role of cAMP in the induction of oocyte maturation. We have found that forskolin can mimic the effect of LH on the ovarian follicle stimulating both cAMP accumulation and ooctye maturation. These findings suggest that LH-induced maturation in follicle-enclosed oocytes is a cAMP-mediated response.

【 授权许可】

Unknown