Forskolin stimulation of thyroid secretion of T4 and T3

FEBS Letters

Laurberg, Peter¹ 

[1] Second University Clinic of Internal Medicine, Kommunehospitalet, DK-8000 Aarhus C, Denmark

关键词: Forskolin;    Thyroid secretion;    Thyroxine;    Triiodothyronine;    cAMP;    Thyroid perfusion;   

DOI  :  10.1016/0014-5793(84)81327-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Forskolin is a potent activator of adenylate cyclase in many tissues including the thyroid gland. We compared the effects of 10⁻⁵ M forskolin and 100 μunits/ml TSH on the dynamics of T₄ and T₃ secretion from perfused dog thyroid lobes. Both agents induced pronounced increases in T₄ and T₃ secretion. The increase in secretion was significantly steeper during forskolin than during TSH stimulation. This may suggest that early processes such as TSH—receptor interaction and the subsequent activation of the catalytic unit of adenylate cyclase are of importance for the pattern of very gradual increase in hormone secretion during TSH stimulation of the thyroid. In other respects forskolin seems to induce absolute and relative secretion of T₃ and T₄ very similar to those obtained by cAMP and TSH.

【 授权许可】

Unknown