Vinblastine‐induced autophagocytosis: effects on liver glycogen

FEBS Letters

Hirsimäki, Pirrko¹ 

[1] Department of Cell Biology, Institute of Biology, University of Jyväskylä, Vapaudenkatu 4, 40100 Jyväskylä 10, Finland

关键词: Vinoblastine;    Autophagocytosis;    Liver;    Glycogen;    cAMP;   

DOI  :  10.1016/0014-5793(83)80349-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The possible similarities of the mechanism by which vinblastine induces autophagocytosis in liver were compared with the known effects of glucagon in glucagon-induced autophagocytosis. A single intraperitoneal injection of vinblastine produced a wave of autophagocytosis in <0.5 h in mouse hepatocytes. Liver glycogen content decreases simultaneously and blood glucose first increased and then decreased below control values. Both liver cAMP concentration and the activity of glycogen phosphorylase remained unchanged. These findings provide evidence tht the induction of autophagocytosis after vinblastine injection is not mediated by cAMP. The increased degradation of glycogen may occur in the lysosomal system by means of increased autophagocytosis.

【 授权许可】

Unknown