Stimulation by silybin, a eukaryotic feature of archaebacterial RNA polymerases

FEBS Letters

Schnabel, R.¹  Zillig, W.¹  Sonnenbichler, J.¹ 

[1] Max-Planck-Institu für Biochemie, 8033 Martinsried, FRG

关键词: Transcription;    Silybin;    Archaebacteria;    Eubacteria;    Eukaryotis;    Evolution;   

DOI  :  10.1016/0014-5793(82)80776-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Transcription of native DNA by DNA-dependent RNA polymerases of members of the thermoacidophilic branch of the archaebacteria like that of eukaryotic RNA polymerase A of rat liver, is stimulated by the flavonolignane derivative silybin. Eubacterial RNA polymerases are not affected. For both RNA polymerase A of rat liver and RNA polymerase of Thermoplasma acidophilum the stimulatory effect is confined to the enhancement of the elongation reaction suggesting a similar mechanism for both enzymes. These results further support a specific phylogenetic relationships between the archaebacteria and the eukaryotic cytoplasm.

【 授权许可】

Unknown