Differential effect of phenobarbital and β‐naphthoflavone on the mRNAs coding for cytochrome P450 and NADPH cytochrome P450 reductase

FEBS Letters

Rabin, Brian R.¹  Pike, Susan F.¹  Shephard, Elizabeth A.¹  Ashworth, Alan¹  Phillips, Ian R.¹ 

[1] Department of Biochemistry, University College London, Gower Street, London, WC1E 6BT, England

关键词: Cytochrome P450;    NADPH cyt. P450 reductase;    mRNA;    Immunoprecipitation;    Phenobarbital;    β-Naphthoflavone;    PB;    phenobarbital;    β-NF;    β-naphthoflavone;    PB P450;    major inducible cytochrome P450 variant of M r 52 000;   

DOI  :  10.1016/0014-5793(82)80771-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The induction in rat liver of a specific variant(s) of cytochrome P450 (PB-P450) by phenobarbital and its repression by β-naphthoflavone occur through corresponding changes in the levels of mRNA coding for the protein(s). The level of translatable mRNA coding for NADPH-cytochrome P450 reductase in rat liver increases on treatment with phenobarbital but not β-naphthoflavone.

【 授权许可】

Unknown