Does translational ambiguity increase during cell differentiation?

FEBS Letters

Picard-Bennoun, Marguerite¹ 

[1] Laboratoire de Génétique de l'Université Paris XI et laboratoire associé au CNRS (86), Bâtiment 400, 91405 Orsay Cedex, France

关键词: Translational fidelity;    Cell differentiation;    Lower eukaryotes;    Ribosomal mutants;   

DOI  :  10.1016/0014-5793(82)81094-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Several observations made in the fungus Podospora anserina suggest that translational ambiguity may increase, and possibly must increase, at specific stages of the life cycle. Such changes in the properties of the translational apparatus seem to occur as well in the yeast S. cerevisiae and in the alga C. reinhardii. A slight increase of the misreading level would allow readthrough or frameshifting necessary to synthesise regulatory proteins in low amount at key points of cellular differentiation.

【 授权许可】

Unknown