A new candidate for the regulation of erythropoiesis

FEBS Letters

Kurtz, Armin¹  Bauer, Christian¹  Jelkmann, Wolfgang¹ 

[1] Institut für Physiologie, Universität Regensburg, Postfach 397, 8400 Regensburg, FRG

关键词: Insulin-like growth factor;    Somatomedin;    Erythroid differentiation;    Erythroid precursor cell;    Cell structure;   

DOI  :  10.1016/0014-5793(82)81081-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of pure human insulin-like growth factor I (IGF I) on the colony formation of late stage erythroid precursor cells (CFU-e) from fetal mouse liver and adult bone marrow was studied in a serum-free culture system. We found that IGF I in physiological concentrations stimulated erythroid colony formation. The combined effect of IGF I and erythropoietin was smaller than the sum of their single effects. The number of colonies induced by IGF I was linearly dependent on the number of plated cells. Our results indicate that IGF I is the first early defined mitogen that stimulates the late stages of erythroid differentiation independently of erythropoietin.

【 授权许可】

Unknown