The mandatory role of complement in the endotoxin‐induced synthesis of tissue thromboplastin in blood monocytes

FEBS Letters

Østerud, Bjarne¹  Eskeland, Trond¹ 

[1] Institute of Medical Biology, University of Tromsø and University Hospital of Tromsø, Tromsø, Norway

关键词: Monocyte;    Thromboplastin synthesis;    Complement;    Endotoxin;   

DOI  :  10.1016/0014-5793(82)81075-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Fres isolated blood cells recombined with normal heparinized plasma and then incubated with endotoxin, induced a 100-fold increase in monocyte tissue thromboplastin synthesis. In contrast, recombination of these cells with heat inactivated plasma, cobra venom factor-treated plasma, Ca²⁺-free plasma, or BioRex 70-treated plasma (plasma free of Clq and D) before incubation with endotoxin, failed to induce monocyte synthesis of tissue thromboplastin. These results strongly support the hypothesis that complement is required for endotoxin stimulation of blood monocyte synthesis of tissue thromboplastin.

【 授权许可】

Unknown