A role for glycosaminoglycans in the development of collagen fibrils

FEBS Letters

Parry, David A.D.⁴  Gillard, Gerald C.¹  Flint, Michael H.³  Craig, Alan S.² 

[1] Department of Biochemistry, University of Auckland, Auckland New Zealand;Applied Biochemistry Division, Department of Scientific and Industrial Research, Palmerston North, New Zealand;Department of Surgery, School of Medicine, University of Auckland, New Zealand;Department of Chemistry, Biochemistry and Biophysics, Massey University, Palmerston North, New Zealand

关键词: Glycosaminoglycan;    Collagen fibril;    Fibrillogenesis;    Connective tissue development;   

DOI  :  10.1016/0014-5793(82)81060-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Extensive data on the glycosaminoglycan (GAG) composition and the collagen fibril diameter distribution have been collected for a diverse range of connective tissues. It is shown that tissues with the smallest diameter collagen fibrils (mass-average diameter < 60 nm) have high concentrations of hyaluronic acid and that tissues with the largest diameter collagen fibrils (mass-average diameter ∼200 nm) have high concentrations of dermatan sulphate. It is suggested that the lateral growth of fibrils beyond a diameter of about 60 nm is inhibited by the presence of an excess of hyaluronic acid but that this inhibitory effect may be removed by an increasing concentration of chondroitin sulphate and/or dermatan sulphate. It is also postulated that high concentrations of chondroitin sulphate will inhibit fibril growth beyond a mass-average diameter of ∼150 nm. Such an inhibition may in turn be removed by an increasing concentration of dermatan sulphate such that it becomes the dominant GAG present in the tissue.

【 授权许可】

Unknown