Glucose inhibits insulin release induced by Na+ mobilization of intracellular calcium

FEBS Letters

Honkanen, Tapio¹  Gylfe, Erik¹  Hellman, Bo¹ 

[1] Department of Medical Cell Biology, University of Uppsala, Biomedicum, S-751 23 Uppsala, Sweden

关键词: Insulin release;    Pancreatic islet;    Ca2+ mobilisation;    Glucose;    Na+ mobilization;    K+ removal;   

DOI  :  10.1016/0014-5793(82)80826-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

⁴⁵Ca²⁺ incorporated in response to glucose was selectively mobilized from the β-cell-rich pancreatic islets of ob/ob-mice after raising the intracellular Na⁺ by removal of K⁺ or addition of ouabain or veratridine. Also studies of insulin release indicated opposite effects of glucose and Na⁺ on the intracellular sequestration of calcium. The fact that glucose inhibits insulin release induced by raised intracellular Na⁺ indicates that this sugar can lower the cytoplasmic [Ca²⁺]. The concept of a dual action of glucose on the cytoplasmic [Ca²⁺]. The concept of a dual action of glucose on the cytoplasmic [Ca²⁺] might well explain previous observations of an inhibitory component in the glucose action on the ⁴⁵Ca²⁺ efflux.

【 授权许可】

Unknown