ASSOCIATION STUDY OF GLUTATHIONE S-TRANSFERASE POLYMORPHISMS AND RISK OF ENDOMETRIOSIS IN AN IRANIAN POPULATION

Iranian journal of reproductive medicine

SALIMINEJAD KIOOMARS¹  KAMALI KOOROSH¹  HEIDARIZADEH MASOOD¹  MEMARIANI TOKTAM¹  KHORRAM KHORSHID HAMID REZA¹  HASSANI MINA¹ 

关键词: ENDOMETRIOSIS;    ASSOCIATION STUDY;    GSTM1;    GSTT1;    GSTP1;    POLYMORPHISM;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Endometriosis influenced by both genetic and environmental factors. Associations of glutathione S-transferases (GSTs) genes polymorphisms in endometriosis have been investigated by various researchers; however, the results are not consistent.Objective: We examined the associations of GSTM1 and GSTT1 null genotypes and GSTP1 313 A/G polymorphisms with endometriosis in an Iranian population.Materials and Methods: In this case-control study, 151 women with diagnosis of endometriosis and 156 normal healthy women as control group were included. The genotyping was determined using multiplex PCR and PCR- RFLP methods.Results: The GSTM1 null genotype was significantly higher (p=0.027) in the cases (7.3%) than the control group (1.3%). There was no significant difference between the frequency of GSTT1 genotypes between the cases and controls. The GSTP1 313 AG genotype was significantly lower (p=0.048) in the case (33.1%) than the control group (44.4%).Conclusion: Our results showed that GSTM1 and GSTP1 polymorphisms may be associated with susceptibility of endometriosis in Iranian women.

【 授权许可】

Unknown