Iranian journal of reproductive medicine | |
ASSOCIATION STUDY OF GLUTATHIONE S-TRANSFERASE POLYMORPHISMS AND RISK OF ENDOMETRIOSIS IN AN IRANIAN POPULATION | |
SALIMINEJAD KIOOMARS1  KAMALI KOOROSH1  HEIDARIZADEH MASOOD1  MEMARIANI TOKTAM1  KHORRAM KHORSHID HAMID REZA1  HASSANI MINA1  | |
关键词: ENDOMETRIOSIS; ASSOCIATION STUDY; GSTM1; GSTT1; GSTP1; POLYMORPHISM; | |
DOI : | |
学科分类:药学、药理学、毒理学(综合) | |
来源: Shahid Sadoughi University of Medical Sciences, Yazd | |
【 摘 要 】
Background: Endometriosis influenced by both genetic and environmental factors. Associations of glutathione S-transferases (GSTs) genes polymorphisms in endometriosis have been investigated by various researchers; however, the results are not consistent.Objective: We examined the associations of GSTM1 and GSTT1 null genotypes and GSTP1 313 A/G polymorphisms with endometriosis in an Iranian population.Materials and Methods: In this case-control study, 151 women with diagnosis of endometriosis and 156 normal healthy women as control group were included. The genotyping was determined using multiplex PCR and PCR- RFLP methods.Results: The GSTM1 null genotype was significantly higher (p=0.027) in the cases (7.3%) than the control group (1.3%). There was no significant difference between the frequency of GSTT1 genotypes between the cases and controls. The GSTP1 313 AG genotype was significantly lower (p=0.048) in the case (33.1%) than the control group (44.4%).Conclusion: Our results showed that GSTM1 and GSTP1 polymorphisms may be associated with susceptibility of endometriosis in Iranian women.
【 授权许可】
Unknown
【 预 览 】
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