Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients

Genetics and Molecular Biology

Claudio Lima Souza²  Cynara Gomes Barbosa²  José Pereira De Moura Neto²  José Henrique Barreto¹  Mitermayer Galvão Reis²  Marilda Souza Gonçalves² 

[1] ,Fundação Oswaldo Cruz Centro de Pesquisas Gonçalo Moniz Laboratório de Patologia e Biologia MolecularSalvador BA ,Brazil

关键词: acute promyelocytic leukemia;    chronic myeloid leukemia;    GSTM1;    GSTT1;    gene polymorphism;   

DOI  :  10.1590/S1415-47572008000100008

来源: SciELO

【 摘 要 】

The null genotype for glutathione S-transferase (GST, EC 2.5.1.18) gene polymorphisms is considered a risk factor for leukemia in different populations. In this work we investigated the GSTT1 and GSTM1 polymorphisms using multiplex PCR in 53 patients with chronic myeloid leukemia (CML), 23 with acute promyelocytic leukemia (APL) and 304 apparently healthy controls. In this association study we found that the GSTT1null genotype was more frequent in our group of APL patients than in the control group [OR = 2.75 (95% CI = 1.10-6.88)], providing evidence that a deletion in the GSTT1 gene could be a risk factor for this type of leukemia.

【 授权许可】

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