THE EFFECT OF ENDOMETRIAL INJURY ON FIRST CYCLE IVF/ICSI OUTCOME: A RANDOMIZED CONTROLLED TRIAL

Iranian journal of reproductive medicine

BAHAA HAITHAM¹  MAHRAN AHMAD¹  IBRAHIM MAHMOUD¹ 

关键词: ENDOMETRIAL INJURY;    IMPLANTATION RATE;    LIVE BIRTH RATE;    IN VITRO FERTILIZATION (IVF);    INTRA CYTOPLASMIC SPERM INJECTION (ICSI);   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Implantation remains a limiting step in IVF/ICSI. Endometrial injury isa promising procedure aiming at improving the implantation and pregnancy rates after IVF/ICSI.Objective: The aim of this study was to evaluate the effect of endometrial injury induced in precedingcycle on IVF/ICSI outcome.Materials and Methods: Four hundred patients undergoing their first IVF/ICSI cycle in two IVF units in Minia, Egypt were randomly selected to undergo either endometrial injury in luteal phase of preceding cycle (intervention group) or no treatment (control group). Primary outcome was the implantation and live birth rates While the secondary outcome was clinical pregnancy, miscarriage, multiple pregnancy rates, pain and bleeding during and after procedure.Results: Implantation and live birth rates were significantly higher in intervention compared with control group (22.4% vs.18.7%, p=0.02 and 67% vs.28%, p=0.03), respectively. There was also a significant reduction in miscarriage rate in intervention group (4.8% vs.19.7%, respectively, p<0.001).Conclusion: Endometrial injury in preceding cycle improves the implantation rate and live birth rate and reduces the miscarriage rate per clinical pregnancy in patients undergoing their first IVF/ICSI cycle.

【 授权许可】

Unknown