INTRAUTERINE ADMINISTRATION OF RECOMBINANT HUMAN CHORIONIC GONADOTROPIN BEFORE EMBRYO TRANSFER ON OUTCOME OF IN VITRO FERTILIZATION/ INTRACYTOPLASMIC SPERM INJECTION: A RANDOMIZED CLINICAL TRIAL

Iranian journal of reproductive medicine

ZOLGHADRI JALEH¹  ALBORZI SAEED¹  AMOOEE SEDIGHEH¹  ARAMESH SHAHINTAJ¹  ZAREI AFSOON¹  PARSANEZHAD MOHAMMAD EBRAHIM¹  YOUNESI MASOUMEH¹  SAMSAMI ALAMTAJ¹ 

关键词: RECOMBINANT HUMAN CHORIONIC GONADOTROPIN (RHCG);    INTRACYTOPLASMIC SPERM INJECTION (ICSI);    IN VITRO FERTILIZATION (IVF);    IMPLANTATION RATE;    PREGNANCY RATE;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: The direct effect of hCG on the human endometrium was studied several times.Objective: The objectives of this study were to evaluate the effectiveness of intrauterine injection of recombinant human chorionic gonadotropin (rhCG) before embryo transfer (ET).Materials and Methods: In this randomized placebo-controlled clinical trial, a total number of 182 infertile patients undergoing their first in vitro fertilization/ intracytoplasmic sperm injection (IVF-ICSI) cycles were randomly assigned to receive 250mg intrauterine rhCG (n=84) or placebo (n=98) before ET. The implantation and pregnancy rates were compared between groups.Results: Patients who received intrauterine rhCG before ET had significantly higher implantation (36.9% vs. 22.4%; p=0.035), clinical pregnancy rates (34.5% vs. 20.4%; p=0.044) and ongoing pregnancy rate (32.1% vs. 18.4%; p=0.032) when compared to those who received placebo. The abortion (2.4% vs. 2.0%; p=0.929) and ectopic pregnancy rates (1.2% vs. 1.0%; p=0.976) were comparable between groups of rhCG and placebo, respectively.Conclusion: Intrauterine injection of 250mg of rhCG before ET significantly improves the implantation and pregnancy rates in IVF/ICSI cycles.

【 授权许可】

Unknown