Iranian journal of reproductive medicine | |
INTRAUTERINE ADMINISTRATION OF RECOMBINANT HUMAN CHORIONIC GONADOTROPIN BEFORE EMBRYO TRANSFER ON OUTCOME OF IN VITRO FERTILIZATION/ INTRACYTOPLASMIC SPERM INJECTION: A RANDOMIZED CLINICAL TRIAL | |
ZOLGHADRI JALEH1  ALBORZI SAEED1  AMOOEE SEDIGHEH1  ARAMESH SHAHINTAJ1  ZAREI AFSOON1  PARSANEZHAD MOHAMMAD EBRAHIM1  YOUNESI MASOUMEH1  SAMSAMI ALAMTAJ1  | |
关键词: RECOMBINANT HUMAN CHORIONIC GONADOTROPIN (RHCG); INTRACYTOPLASMIC SPERM INJECTION (ICSI); IN VITRO FERTILIZATION (IVF); IMPLANTATION RATE; PREGNANCY RATE; | |
DOI : | |
学科分类:药学、药理学、毒理学(综合) | |
来源: Shahid Sadoughi University of Medical Sciences, Yazd | |
【 摘 要 】
Background: The direct effect of hCG on the human endometrium was studied several times.Objective: The objectives of this study were to evaluate the effectiveness of intrauterine injection of recombinant human chorionic gonadotropin (rhCG) before embryo transfer (ET).Materials and Methods: In this randomized placebo-controlled clinical trial, a total number of 182 infertile patients undergoing their first in vitro fertilization/ intracytoplasmic sperm injection (IVF-ICSI) cycles were randomly assigned to receive 250mg intrauterine rhCG (n=84) or placebo (n=98) before ET. The implantation and pregnancy rates were compared between groups.Results: Patients who received intrauterine rhCG before ET had significantly higher implantation (36.9% vs. 22.4%; p=0.035), clinical pregnancy rates (34.5% vs. 20.4%; p=0.044) and ongoing pregnancy rate (32.1% vs. 18.4%; p=0.032) when compared to those who received placebo. The abortion (2.4% vs. 2.0%; p=0.929) and ectopic pregnancy rates (1.2% vs. 1.0%; p=0.976) were comparable between groups of rhCG and placebo, respectively.Conclusion: Intrauterine injection of 250mg of rhCG before ET significantly improves the implantation and pregnancy rates in IVF/ICSI cycles.
【 授权许可】
Unknown
【 预 览 】
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RO201912010273204ZK.pdf | 403KB | download |