VAGIFEM IS SUPERIOR TO VAGINAL PREMARIN IN INDUCTION OF ENDOMETRIAL THICKNESS IN THE FROZEN-THAWED CYCLE PATIENTS WITH REFRACTORY ENDOMETRIA: A RANDOMIZED CLINICAL TRIAL

Iranian journal of reproductive medicine

BEHDIN SHABNAM¹  HAGHBIN HOSSEIN¹  ZOLGHADRI JALEH¹  DADRAS NASRIN¹ 

关键词: PREMARIN;    ESTRADIOL;    ENDOMETRIUM;    INFERTILITY;    HUMAN;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Embryo transfer to a developed endometrium is an important prognostic factor in frozen-thawed embryo transfer cycle outcome. Vaginal estrogen, such as Vagifem vaginal tablets and Premarin vaginal cream, is a regimen used for the patients with refractive endometria.Objective: Our objective was to compare the effects of Vagifem and Premarin on the endometrial thickness of the patients with refractive endometria.Materials and Methods: In this randomized clinical trial, 30 patients with refractive endometria in frozen-thawed embryo transfer cycles received Vagifem vaginal tablets and 30 women received Premarin vaginal cream. Endometrial thickness was measured on the 14th day of drug administration.Results: Comparing the endometrial thicknesses of the two groups showed that the endometria of the Vagifem group was significantly thicker than that of the Premarin group (5.93±0.38 vs. 6.74±0.32; p<0.001).Conclusion: Vagifem is superior to Premarin in induction of endometrial thickness in frozen-thawed embryo transfer cycles in the patients with refractive endometria.

【 授权许可】

Unknown