EFFECT OF INTRAMURAL MYOMECTOMY ON ENDOMETRIAL HOXA10 AND HOXA11 MRNA EXPRESSION AT THE TIME OF IMPLANTATION WINDOW

Iranian journal of reproductive medicine

ESNA ASHARI FARZANEH¹  SAIDIJAM MASSOUD¹  SHABAB NOOSHIN¹  FARIMANI SANOEE MARZIEH¹  ALIZAMIR TAHEREH¹  FARAMARZI SHAMILA¹  ALIZADEH ZOHREH¹ 

关键词: MYOMA;    UTERINE MYOMECTOMY;    HOXA11;    HOXA10;    ENDOMETRIUM;    EMBRYO IMPLANTATION;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: HOXA11 and HOXA10 are expressed in endometrium throughout the menstrual cycle and show a dramatic increase during the mid-luteal phase at the time of implantation. The expression of these genes is decreased in women with myomas.Objective: To determine whether myomectomy would reverse HOXA11 and HOXA10 expression, we evaluated the transcript levels of these genes in the endometria of patients before and after myomectomy.Materials and Methods: Expression of HOXA11 and HOXA10 were examined prospectively during the midluteal phase in endometrium obtained from infertile women (n=12) with myoma before and three months after myomectomy. Endometrial HOXA11 and HOXA10 expression were evaluated using quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR).Results: Endometrial HOXA11 and HOXA10 mRNAs expression levels (normalized to 18SrRNA) were increased insignificantly in endometrium of patients after myomectomy (p=0.7 and p=0.15 respectively).Conclusion: The results suggest that the alteration in expression pattern of these genes could not account for some aspects of fertility after myomectomy.

【 授权许可】

Unknown