PROPOFOL OR THIOPENTAL SODIUM IN PATIENTS UNDERGOING REPRODUCTIVE ASSISTED TECHNOLOGIES: DIFFERENCES IN HEMODYNAMIC RECOVERY AND OUTCOME OF OOCYTE RETRIEVAL: A RANDOMIZED CLINICAL TRIAL SHORT COMMUNICATION

Iranian journal of reproductive medicine

DEHGHAN TEZERJANI MOHAMMAD¹  MOUSAVI FATEMEH SADAT¹  SOLTANI HAMID REZA¹  JOUYA REZA¹  JARAHZADEH MOHAMMAD HOSSEIN¹  BEHDAD SHEKOOFA¹ 

关键词: THIOPENTAL SODIUM;    PROPOFOL;    ASSISTED REPRODUCTIVE TECHNOLOGY;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Thiopental sodium and Propofol are two widely-used drugs in the induction of anesthesia in assisted reproductive technology (ART). However, the side effects and outcome of recovery from anesthesia of these drugs on ART have not been identified yet.Objective: This study aimed at investigating the side effects and hemodynamic effects of using thiopental sodium and propofal as well as effects of these drugs on pregnancy outcome in ART cycles.Materials and Methods: In this double blinded) randomized controlled trial, 90 woman candidate for ART were randomly divided into two groups. 47 patients received Propofol (2.5 mg/kg) and 43 patients received thiopental (5 mg/kg) for anesthesia induction. The entry hemodynamic parameters of the patients were documented. During the anesthesia process, hemodynamic parameters were checked at five-minute intervals.Results: The results of the study showed a statistically significant difference between two groups in terms of their response to verbal stimulation (p<0.001), the normalization time of the rate and quality of breathing (p<0.001), nausea (p<0.001), and vomiting (p<0.001). Also, in comparison with the other group, all these parameters were better in Propofol group. There was found no significant difference between two groups in terms of other variables.Conclusion: Based on the findings of the study, Propofol has fewer known side effects. Vomiting and nausea as two known side effect of anesthesia are significantly lower in patients receiving Propofol than patients who received thiopental.

【 授权许可】

Unknown