RESULTS FROM ADDING RECOMBINANT LH FOR ASSISTED REPRODUCTIVE TECHNOLOGY TREATMENT: A RANDOMIZED CONTROL TRIAL

Iranian journal of reproductive medicine

DEHGHANI FIROUZABADI RAZIEH¹  JANATI SIMA¹  RAZI MOHAMMAD HOSSEIN¹  MOHSENI FERESHTEH¹  YARI NAHID¹  ETEBARY SAHABEH¹ 

关键词: ASSISTED REPRODUCTIVE TECHNOLOGY;    OVARIAN STIMULATION;    GONADOTROPIN STIMULATION;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Based on classical two-cell, two-gonadotropin theory, in the follicle, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) put on their main effects on the granulosa and theca cells. LH is essential for androgens production. Androgens are used for estradiol production by granulosa cells. Profound suppression of LH concentrations in some normogonadotropic patients can cause several adverse effects.Objective: The main clinical purpose of this study was that normoresponder women treated with controlled ovarian super ovulation for IVF or ICSI may benefit from co-administration of rLH.Materials and Methods: 40 patients who were candidates for assisted reproductive technology (ART) were randomly selected. In all patients long luteal protocol was used for ovulation induction. Patients were randomly divided into two groups: Group 1 (n=20) with standard long protocol (GnRH agonist) and r-FSH alone, Group 2 (n=20) with standard long protocol (GnRH agonist) and r-FSH with r-LH. Results were statistically analyzed and compared in two groups.Results: The number of retrieved oocytes, mature oocytes, cleaved embryos, transferred embryos, estradiol levels in Human chorionic gonadotropin (hCG) administration day, implantation rate and clinical pregnancy rate in group 2 were higher but not significantly different.Conclusion: Administration of rLH in late follicular phase had no beneficial effect on outcomes in young women with mean age of 31 years. Maybe a greater sample size should be used to see the effects more accurately; also it is possible that rLH will be useful in older patients.

【 授权许可】

Unknown