COMPARISON OF RECOMBINANT HUMAN FOLLICLE STIMULATING HORMONE (RHFSH), HUMAN CHORIONIC GONADOTROPIN (HCG) AND HUMAN MENOPAUSAL GONADOTROPIN (HMG) ON SEMEN PARAMETERS AFTER VARICOCELECTOMY: A RANDOMIZED CLINICAL TRIAL

Iranian journal of reproductive medicine

BABBOLHAVAEJI HOOSHANG¹  YAVANGI MAHNAZ¹  AMIRZARGAR HOSSEIN¹  MOADABSHOAR LEILA¹  AMIRZARGAR MOHAMMAD ALI¹  BASIRI ABBAS¹  AMIRZARGAR NASIBEH¹  HOSSEINI MOGHADDAM SAYYED MAHDI¹ 

关键词: MALE INFERTILITY;    SEMEN ANALYSES;    VARICOCELE;    VARICOCELECTOMY;    HCG;    HMG;    RHFSH;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: The most frequent physical finding in infertile men is varicocele, in which one of the mechanisms that can affect seminal parameters is oxidative stress.Objective: Our study aimed, for the first time, to compare the efficacy of recombinant human follicle-stimulating hormone (rhFSH), human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG) on sperm parameters and fertility after varicocelectomy.Materials and Methods: 113 infertile men with varicocele were divided into four groups. Group A received HCG 5000 IU weekly, group B received HMG 75 IU three times a week, group C received rhFSH 75 IU three times a week and group D received no medical treatment after varicocelectomy.Results: After three months, in group A sperm morphology improved (p=0.007), causing a 32% pregnancy rate. In group B, sperm motility (p=0.023) and morphology (p=0.014) improved, causing a 57% pregnancy rate. In group C, all of the investigated semen parameters increased (p<0.05), causing a 62.5% pregnancy rate. Only rhFSH improved sperm concentrations to>20�?106 mL (p=0.027). In group D, sperm morphology increased (p=0.038), but other parameters remained unchanged and no pregnancies occurred.Conclusion: It can be concluded that drugs can reduce induction time for spermatogenesis and fertility in comparison with varicocelectomy alone. For these purposes, rhFSH is more effective than other drugs.

【 授权许可】

Unknown