Relation between obesity and the oestrogen receptor status of breast cancer

Malta medical journal

Etienne Mark Paris¹  Gordon Caruana Dingli¹  David Pisani¹ 

关键词: Body Mass Index;    Obesity;    Age;    Oestrogen Receptor;    Breast Cancer;   

DOI  :  

学科分类：医学（综合）

来源: University of Malta * Medical School

【 摘 要 】

Introduction: Obesity is a growing problem in the Western world. Correlations have been found between increasing body mass index (BMI) and breast cancer. The objectives were to establish whether a relationship exists between BMI and breast cancer and to investigate any association between BMI and tumour oestrogen receptor expression. Method: Clinical and socio-demographic details (age, menopausal status, height and weight) of a sample of women with breast cancer operated in 2010 were collected, dividing the group into oestrogen receptor positive (ER+) and negative (ER–) subgroups. The average BMI of each subgroup was compared to the mean BMI of a sample of the general Maltese female population obtained from the European Health Examination Survey 2010 Report (Pilot Study) by virtue of an ANOVA test. Subsequently, the relations between oestrogen receptor expression and each of menopausal status, age and BMI were statistically analysed using chi-squared analysis and two-sample t-tests. Results: A total of 103 patients were studied. 72 patients (age range: 40 – 90 years) had ER+ malignancy and 31 patients (29 – 81 years) had ER- malignancy. The mean BMI’s of the ER+ and ER- subgroups were 30.1 and 27.1 respectively, while that of the female general population (29 – 90 years) was 28.4. Analysis revealed a significant difference between the BMI’s of the ER+ and ER- subgroups (p

【 授权许可】

Unknown