Nicotine: Pharmacology and Therapeutic Implications in Neurodegenerative and Psychiatric Disorders

Malta medical journal

Charles Scerri¹ 

关键词: Nicotine;    smoking;    withdrawal;    Parkinson's disease;    Alzheimer's disease;    depression;    schizophrenia;    anxiety;    psychiatric disorders;   

DOI  :  

学科分类：医学（综合）

来源: University of Malta * Medical School

【 摘 要 】

The pathophysiology of tobacco-related diseases is complex and multifactorial. Among the various compounds in tobacco smoke are carcinogens such as nitrosamines, irritants such as a variety of phenolic compounds, volatiles such as carbon monoxide, and of course nicotine. Nicotine itself has quite complex actions, mediated in part by nicotinic cholinergic receptors that may have extraneuronal, as well as neuronal distribution. Its actions have also been implicated in a variety of neurodegenerative and psychiatric disorders. This short review discusses the recent pharmacology of nicotine and recent progress on its possible therapeutic benefits.

【 授权许可】

Unknown