Effect of Antiretroviral Drug (arved) on the Kidney in Albino Rat

Journal of Applied Sciences and Environmental Management

UWAKWE, A.A.¹  MONAGO, C.C.¹  PETERS, D.E.¹ 

关键词: HIV;    AIDS;    Antiretroviral Drugs;    Arved;    Zidovudine;    Lamivudine;    Creatinine;    Urea;    Potassium ion;    Sodium ion;    hypokalemia;   

DOI  :  

学科分类：环境科学（综合）

来源: University of Port Harcourt * Department of Pure and Industrial Chemistry

【 摘 要 】

African studies on effect of antiretroviral drugs on the kidney are limited resulting to scanty information on the safety of these drugs. This study was therefore designed to evaluate the effects of antiretroviral drugs arved® , on creatinine, urea, potassium and sodium ions as well as histological effect on the kidney. A total of fifty two (52) albino rats were randomly divided into four groups labeled A, B, C and D and kept in a well ventilated room. All experimental groups shared the same environmental conditions. Group A served as the control and rats were treated with distil water. Rats in groups B, C and D were, respectively treated with three different doses of arved (1.07, 3.21, and 4.29 mg kg-1). The drug was administered orally daily for 2, 4, 6, and 8 consecutive weeks. Animals were sacrificed twenty four hours after the last treatment. Blood samples were collected into heparinized sample bottles for biochemical analyses. The result of this study revealed a significant decrease (p

【 授权许可】

Unknown