Effect of antiretroviral drug (arved) on hepatic enzymes in albino rats

Journal of Applied Sciences and Environmental Management

UKAKWE, A.A.¹  MONAGO, C.C.¹  PETERS, D.E.¹ 

关键词: HIV;    AIDS;    Antiretroviral Drugs;    Arved;    Zidovudine;    Lamivudine;    Alkaline phosphate (ALP);    Aspartate amino transferase (AST);    Alanine amino transferase (ALT);    hepatocellular necrosis;   

DOI  :  

学科分类：环境科学（综合）

来源: University of Port Harcourt * Department of Pure and Industrial Chemistry

【 摘 要 】

In the rush to put as many patients as possible on a potent ART, with very little or no laboratory monitory, limited attention has been given to side effects. This study was therefore designed to evaluate the effects of antiretroviral drugs arved® , on aspartate amino transferase (AST), alanine amino transferase (ALT) and alkaline phosphatase (ALP) activities as well as histological effect on the liver tissue. A total of fifty two (52) albino rats were randomly divided into four groups labeled A, B, C and D and kept in a well ventilated room. All experimental groups shared the same environmental conditions. Group A served as the control and rats were treated with distil water. Rats in groups B, C and D were, respectively treated with three different doses of arved (1.07, 3.21, and 4.29 mg kg-1), The drug was administered orally daily for 2, 4, 6, and 8 consecutive weeks. Animals were sacrificed twenty four hours after the last treatment. Blood samples were collected into heparinized sample bottles for biochemical analysis. Result obtained in this study revealed that arved dose and time dependently, significantly (P

【 授权许可】

Unknown