Effect of rifampicin on the kidney of albino rats

Journal of Applied Sciences and Environmental Management

PETERS, D.E¹  CHIKE, A.O¹ 

关键词: Rifampicin Tuberculosis;    Urea;    creatinine;    Sodium;    Potassium;    Chloride;    Bicarbonate;   

DOI  :  

学科分类：环境科学（综合）

来源: University of Port Harcourt * Department of Pure and Industrial Chemistry

【 摘 要 】

The study was designed to investigate the effect of rifampicin on the kidney biomarkers and histopathology of kidney of albino rats. 42 albino rats were used and rifampicin was administered at 1.10mg/120gBW and 0.55mg/120gBW for intervals of 20, 40 and 60days.Animals were sacrificed 24 hours after the last day of administration and blood samples were collected for the estimation of urea and creatinine levels sodium , potassium, chloride and bicarbonate ion concentrations. Result from this study indicates that urea and creatinine levels in a dose and time dependent manner, significantly increased (p

【 授权许可】

Unknown