Impact of ligating gonadal or adrenal collateral veins with the left renal vein on renal function and histology in right-nephrectomized rats

INTERNATIONAL JOURNAL OF SURGERY

卷:7

Article

Yucel, Tayfun²  Ekiz, Feza³  Gurdal, Sibel Ozkan⁴  Yavuz, Hasan⁵  Koksoy, Ferda Nihat¹  Sit, Mustafa⁶  Igdem, Aysenur Akyildiz⁷  Sahan, Elife⁷ 

[1] Taksim Egitim & Arastirma Hastanesi, Genel Cerrahi Klin 1, Minist Hlth, Dept Surg, TR-34433 Istanbul, Turkey

[2] Sakarya Univ, Sakarya Med Sch, Dept Surg, Sakarya, Turkey

[3] Kosuyolu Yuksek Ihtisas Hosp, Dept Gastrointestinal Surg, Minist Hlth, Istanbul, Turkey

[4] Namik Kemal Univ, Namik Kemal Med Sch, Dept Surg, Tekirdag, Turkey

[5] Zeynep Kamil Training & Res Hosp, Dept Surg, Minist Hlth, Istanbul, Turkey

[6] Dogubayazit State Hosp, Dept Surg, Minist Hlth, Agri, Turkey

[7] Taksim Egitim & Arastirma Hastanesi, Minist Hlth, Dept Pathol, TR-34433 Istanbul, Turkey

关键词: Right nephrectomy;    Left renal vein;    Gonadal vein;    Adrenal vein;    Ligation;    Urea;    Creatinine;    Sodium;    Potassium;    Ischemic cortical necrosis;   

DOI  :  10.1016/j.ijsu.2009.05.006

来源: Elsevier

【 摘 要 】

Background: In cases of trauma to the left renal vein (LRV), its ligation near the inferior vena cava (IVC) is considered, but the consequences are not always good. We investigated the role of collateral venous drainage after ligation of the LRV by studying the renal function and histology after ligation of the LRV near the IVC alone or with ligation of the gonadal or adrenal collaterals, in right-nephrectomized (RN) rats. Material and methods: Ligation of the LRV near the IVC alone (group 1) or with ligation of the adrenal (group 2) or gonadal (group 3) collaterals was studied in RN Wistar rats (n = 18 per group). The renal histopathology (ischemic cortical necrosis) and functional status (urea, creatinine, sodium, and potassium) were compared. Results: In RN rats, the results were better when ligating the LRV near the IVC alone or with the adrenal collaterals [mortality 4/18 (22.2%) and 3/18 (16.7%), respectively] than when ligating the LRV near the IVC plus the gonadal collaterals [mortality 15/18 (83.3%)] (p < 0.0001). All early deaths occurred within three days and resulted from serious histopathological (ischemic cortical necrosis) and functional (increased urea, creatinine, and potassium; decreased sodium) renal damage. Conclusion: In right-nephrectomized rats, the LRV near the IVC and the adrenal collateral can be ligated, while the gonadal collateral should be preserved. Published by Elsevier Ltd on behalf of Surgical Associates Ltd.

【 授权许可】

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