Biological Toxicities and Aggregation Effects of L-Glycine and L-Alanine Capped ZnS:Mn Nanocrystals in Aqueous Solution

Bulletin of the Korean chemical society

Jonghoe Byun¹  Byungkwan Song¹  Sanghyun Park¹  Cheong-Soo Hwang¹  Hoon Young Kong¹ 

关键词: ZnS:Mn nanocrystal;    Glycine capping;    Alanine capping;    Cytotoxicity;    Aggregation;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

In this study, water-dispersible ZnS:Mn nanocrystals were synthesized by capping the surface with conventional and simple structured amino acid ligands: L-Glycine and L-Alanine. The ZnS:Mn-Gly and ZnS:Mn-Ala nanocrystal powders were characterized by XRD, HR-TEM, EDXS, ICP-AES, and FT-IR spectroscopy. The optical properties were measured by UV-Visible and photoluminescence (PL) spectroscopy. The PL spectra for the ZnS:Mn-Gly and ZnS:Mn-Ala showed broad emission peaks at 599 nm and 607 nm with PL efficiencies of 6.5% and 7.8%, respectively. The measured average particle size from the HR-TEM images were 6.4 ± 0.8 nm (ZnS:Mn-Gly) and 4.1 ± 0.5 nm (ZnS:Mn-Ala), which were also supported by Debye-Scherrer calculations. In addition, the degree of aggregation of the nanocrystals in aqueous solutions were measured by a hydrodynamic light scattering method, which showed formation of sub-micrometer size aggregates for both ZnS:Mn-Gly (273 ± 94 nm) and ZnS:Mn-Ala (233 ± 34 nm) in water due to the intermolecular attraction between the capping amino acids molecules. Finally, the cytotoxic effects of ZnS:Mn-Gly and ZnS:Mn-Ala nanocrsystals over the growth of wild type E. coli were investigated. As a result, no toxicity was shown for the ZnS:Mn-Gly nanocrystal in the colloidal concentration region from 1 μg/mL to 1000 μg/mL, while ZnS:Mn- Ala showed significant toxicity at 100 μg/mL.

【 授权许可】

Unknown