A Quinoline-thiooxorhodamine Conjugate for Fluorescent Hg2+ Recognition in Aqueous Media and Living Cells

Bulletin of the Korean chemical society

Zhenlong Huang¹  Xin Wen¹  Lijun Tang¹  Di Wu¹  Xin Dai¹ 

关键词: Fluorescence;    Hg(II) recognition;    Rhodamine;    Cell imaging;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A quinoline-thiooxorhodamine conjugate fluorescent sensor (1) has been synthesized. Sensor 1 exhibits high selectivity and sensitivity to Hg2+ in H2O/DMSO (95/5, v/v, HEPES 20 mM, pH = 7.4) solution with fluorescence detection. Other tested metal ions do not induce any significant fluorescence intensity changes. Sensor 1 interacts with Hg2+ through a 1:1 binding stoichiometry with a good anti-inference ability. In addition, fluorescent imaging of Hg2+ in Hela cells is also successfully demonstrated.

【 授权许可】

Unknown