Facile Synthesis of Mollugin by Kinetic Control and anti-HCV (Hepatitis C Virus) Activity of Its Analogues

Bulletin of the Korean chemical society

Jong Woo Kim¹  Cheol Gi Kim¹  Na Ri Lee¹  Jong-Gab Jun¹  Sang Wook Lee¹  Da Hye Choi¹ 

关键词: Mollugin;    Hepatitis C virus;    Rubiaceae;    Kinetic control;    Dihydrobenzochromene;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Mollugin has been reported to have various biological activities including antineoplastic, antitumor, antiviral against the hepatitis B virus, anti-aging and antimutagenic activities. An effective and concise synthesis of mollugin in two steps including kinetic control from the cheap starting material 1,4-naphthoquinone has been introduced, and mollugin derivatives thus prepared are screened for their inhibition ability against the hepatitis C virus (HCV) and the dihydrobenzochromene structure might be an additional anti-HCV agent as a new leading compound.

【 授权许可】

Unknown