Regioselective Synthesis of 1,3,4,5-Tetrasubstituted Pyrazoles from α-Alkenyl-α,β-Enones Derived from Morita-Baylis-Hillman Adducts

Bulletin of the Korean chemical society

Jae Nyoung Kim¹  Sung Hwan Kim¹  Jin Woo Lim¹  Jin Yu¹ 

关键词: Pyrazoles;    -Alkenyl-;    -enones;    Morita-Baylis-Hillman adducts;    1;    3-H shift;    Aerobic oxidation;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Convenient synthetic method for 4-arylethylpyrazoles and 4-styrylpyrazoles was developed using α-alkenyl- α,β-enones readily accessed from the Morita-Baylis-Hillman reaction. For the synthesis of 4-arylethylpyrazole, the reactions with arylhydrazines needed to be carried out in o-dichlorobenzene under N2 balloon atmosphere. On the other hand, 4-styrylpyrazoles required the reactions in ethanol under O2 balloon atmosphere.

【 授权许可】

Unknown