Synthesis of Diblock Codendrimer by Double Click Chemistry

Bulletin of the Korean chemical society

Sung-Ho Jin¹  Jae Wook Lee¹  Won Ho Ji¹  Ji Hyeon Kim¹  Seung Choul Han¹ 

关键词: Alkyne;    Azide;    Click reaction;    Diblock dendrimer;    Triazole;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Efficient double click methods for the synthesis of diblock codendrimers were developed. The synthetic strategy involved the sequential click reactions between an alkyne and an azide. The short core building block, 1,4-diazidobutane, was chosen to serve as the azide functionalities for dendrimer growth via click reactions with the alkyne-functionalized PAMAM dendrons as hydrophilic dendron and alkyne-functionalized Fréchettype dendrons as hydrophobic dendron. The structure of diblock codendrimers was confirmed by 1H and 13C NMR spectroscopy, IR spectroscopy, mass spectrometry, and GPC analysis.

【 授权许可】

Unknown