Triazinylmethylphenyl Glucoside as Novel C-Aryl Glucoside SGLT2 Inhibitors

Bulletin of the Korean chemical society

Min Ju Kim¹  Suk Youn Kang¹  Jinhwa Lee¹ 

关键词: SGLT;    Dapagliflozin;    Triazine;    Glucoside;    Diabetes;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Novel C-aryl glucoside SGLT2 inhibitors containing triazine motif were designed and synthesized for biological evaluation. Among the compounds assayed, triazine containing methoxy moiety 18 demonstrated the best in vitro inhibitory activity against hSGLT2 in this series to date (IC50 = 24.9 nM).

【 授权许可】

Unknown