Palladium-Catalyzed Cross-Coupling Reaction and Gold-Catalyzed Cyclization for Preparation of Ethyl 2-Aryl 2,3-Alkadienoates and α-Aryl γ-Butenolides

Bulletin of the Korean chemical society

Phil Ho Lee¹ 

关键词: Palladium;    Gold;    Indium;    Cross-coupling reaction;    Cyclization;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Efficient synthetic method for the preparation of ethyl 2-aryl-2,3-alkadienoates through Pd-catalyzed selective allenyl cross-coupling reactions of aryl iodides with organoindiums generated in situ from indium and ethyl 4- bromo-2-alkynoate was developed. The cyclization reaction of ethyl 2-aryl-2,3-alkadienoates catalyzed by AuCl3 and AgOTf in the presence of AcOH or TfOH produced various α-aryl γ-butenolides or γ-substituted α- aryl γ-butenolides.

【 授权许可】

Unknown