Efficient Ultrasound Enhance Novel Series of 2-((E)-2,3-Dihydro-2-(4- (phenylthio)phenyl)benzo[b][1,4]thiazepin-4-yl)phenol as an Antimicrobial Agent

Bulletin of the Korean chemical society

Charansingh H. Gill¹  Sanjay K. Dabhade¹  Ratnadeep S. Joshi¹  Asha V. Chate¹  Pravin V. Badadhe¹ 

关键词: 1;    5-Benzothiazepines;    Chalcones;    Antimicrobial activity;    Ultrasonication.;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

An efficient synthesis of 1,5-Benzothiazepines via Michael addition of corresponding (E)-1-(2-hydroxyphenyl)- 3-(4-(phenylthio)phenyl)prop-2-en-1-one is described under ultrasound irradiation. A series of novel 2-((E)- 2,3-dihydro-2-(4-(phenylthio)phenyl)benzo[b][1,4]thiazepin-4-yl)phenol derivatives was confirmed on the basis of 1H NMR, Mass, IR spectral data and Elemental analysis. The synthesized compounds were evaluated for their antimicrobial activities. Most of the compounds were found to be comparable potent than the reference standard drugs. Utilization of ultrasound irradiation, simple reaction conditions, isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.

【 授权许可】

Unknown