Synthesis and Characterization of New 3,5-Dinaphthyl Substituted 2-Pyrazolines and Study of Their Antimicrobial Activity

Molecules

Davood Azarifar¹ 

关键词: Chalcones;    (Naphthalene-/substituted naphthalene-1-yl)-2-pyrazolines;    Aryl substituted pyrazolines;    Pyrazolines;    Antimicrobial activity;    Heterocyclics;   

DOI  :  10.3390/71200885

来源: mdpi

【 摘 要 】

A number of chalcones were prepared by condensing either 1‑acetylnaphthalene or substituted 1-acetylnaphthalenes with 1-naphthaldehyde or 4‑dimethylamino-1-naphthaldehyde in ethanolic NaOH solutions. These chalcones were immediately reacted with hydrazine hydrochloride, phenyl hydrazine and semicarbazide hydrochloride in the presence of dry acetic acid to obtain the corresponding 2‑pyrazolines. The synthesised heterocycles were characterized on the basis of their chemical properties and spectroscopic data. These compounds were tested for antimicrobial activity against a variety of test organisms: Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabillis, Shigella dysentry and Salmonella typhii. The compounds containing chloro, hydroxo and dimethylamino -N(CH₃)₂ group as substituents on the naphthalene rings have been found to be very effective antimicrobial agents. In addition, the presence of a carboxamido -CONH₂ substituent group at the N-1 position of the 2-pyrazoline rings is shown to contribute substantially to the antimicrobial activity.

【 授权许可】

Unknown   
© 2002 by MDPI (http://www.mdpi.org).