Positively Charged Silver Nanoparticles Threaded on Carbon Nanotube for the Efficient Delivery of Negatively Charged Biomolecules

Bulletin of the Korean chemical society

Hae-Won Kim¹  Ji-Young Hwang¹  Myoung-Seon Gong¹  Hyung-Seok Park¹  Ueon Sang Shin¹ 

关键词: Carbon nanotubes;    Silver nanoparticle;    Positively charged nanohybrid;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Silver nanoparticle (Ag-NPs)-immobilized and amine-functionalized carbon nanotubes (MWCNTs), MWCNTAg- NH2, were easily prepared in order to develop an efficient delivery system of biomolecules without complicated processes of manufacture. For this, Ag-NPs-immobilized MWCNTs, MWCNT-Ag, were initially prepared in order to create large surface area to enable more efficient linkage with guest-molecules using pristine MWCNTs. The Ag-NPs on MWCNTs were further positively functionalized with 2-aminoethanthiol to allow ionic linkage with biomolecules. Ultimately, the positively charged delivery system proved to be highly effective for the binding capacity of bovine serum albumin (BSA) as a negatively charged model protein, when compared to that of lysozyme used as a positively charged model protein. The releasing profile of BSA was observed in almost linear pattern for about two weeks in a saline solution. This study demonstrated the potential usefulness of the pristine MWCNTs in conjunction with Ag-NPs for the selective delivery of many (negatively or positively) charged biomolecules including proteins and genes.

【 授权许可】

Unknown