Design and Synthesis of Resin-Conjugated Tamiflu Analogs for Affinity Chromatography

Bulletin of the Korean chemical society

Takashi Kuzuhara¹  Masakatsu Shibasaki¹  Kenzo Yamatsugu¹  Motomu Kanai¹  Noriko Echigo¹  Yasuaki Kimura¹ 

关键词: Tamiflu;    Immobilization;    Affinity chromatography;    Abnormal behavior;    Neuraminidase;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Two types of resin-conjugated Tamiflu analogs were synthesized by modifying our original synthetic route of oseltamivir phosphate (Tamiflu). The prepared resins bound to influenza virus neuraminidase, the main target of Tamiflu. The resins will be useful for isolating and identifying presumed endogenous vertebrate proteins that interact with Tamiflu, which might relate to the rarely observed abnormal behavior exhibited by some influenza patients treated with Tamiflu.

【 授权许可】

Unknown