Mitochondrial Affinity of Guanidine-rich Molecular Transporters Built on myo- and scyllo-Inositol Scaffolds: Stereochemistry Dependency

Bulletin of the Korean chemical society

Boram Kim¹  Subhash C Ghosh¹  Young Tae Chang¹  Sung Kee Chung¹  Wanil Kim¹  Chang Nim Im¹  Jungkyun Im¹  Kyong Tai Kim¹  Woo Sirl Lee¹ 

关键词: Blood-brain barrier;    Cellular membrane;    Drug delivery;    Inositol scaffold;    Mitochondrial affinity;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

We prepared several novel molecular transporters built on myo- and scyllo-inositol scaffolds with variations in the number of guanidine residues, linker chain lengths and patterns. Some of these transporters were found to localize in mitochondria, and the mitochondrial affinity seems to be substantially related to the scaffold stereochemistry.

【 授权许可】

Unknown