A Study of Antibacterial Activity of Some Novel 8-Methoxy-4-methyl-quinoline Derivatives

Bulletin of the Korean chemical society

Vikas Kumar¹  Sheoraj Singh¹  Piyush Dua¹  Ashok Kumar¹  Shalabh Sharma¹ 

关键词: Quinoline;    Schiff base;    Azetidinone;    Thiazolidinone;    Antibacterial activity;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

In the present study, some quinoline derivatives have been synthesized like 8-methoxy-4-methyl-2-amino-(3`-chloro- 2`-oxo-4`-substituted aryl-1`-azetidinyl)quinolines 8-12 and 8-methoxy-4-methyl-2-amino-(2`-substituted aryl-4`-oxo- 1`,3`-thiazolidin-3`-yl) quinolines 13-17 from 8-methoxy-4-methyl-2-(substituted arylidenyliminoamino)-quinolines 3-7. The structural assignments of these compounds were based on spectral (IR, 1H-NMR, Mass) and elemental (C, H, N) analysis. Further, these compounds were evaluated for antibacterial activity against various bacterial strains. Three compounds 10, 11 and 16 were found to exhibit potent antibacterial activity as compared to the standard drug amphicillin.

【 授权许可】

Unknown