Discovery of Novel 1,4-Benzodioxane Containing Thiazolidinone Derivatives as Potential Antihepatotoxic Agent

Bulletin of the Korean chemical society

Bahar Ahmed¹  Shamshir Khan¹  Mohamed Jawed Ahsan¹  Habibullah Khalilullah¹ 

关键词: 1;    4-Benzodioxane;    Thiazolidinone;    Antihepatotoxic activity;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

In continuance of our search for newer antihepatotoxic agents some novel thiazolidinone derivatives containing 1,4-benzodioxane ring system were synthesized starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesized compounds were evaluated for antihepatotoxic activity against CCl4-induced hepatotoxicity in rats. Among them some compounds have shown significant antihepatotoxic activity comparable to standard drug silymarin.

【 授权许可】

Unknown