Anti-Cancer Activity of T-Type Calcium Channel Blocker In Vivo

Bulletin of the Korean chemical society

Chun Rim Oh¹  So Hyung Lee¹  Dong Joon Choo¹  Young Deuk Kim¹  Hang Ah Park¹  Jae Yeol Lee¹  Min Sik Min¹  Soo Yeon Jung¹  Kyung Tae Lee¹  Han Byul Kang¹  Jungahn Kim¹ 

关键词: 3;    4-Dihydroquinazoline;    Acute toxicity;    A549 Xenograft;    Anti-cancer;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

3,4-Dihydroquinazoline 1 as T-type calcium channel blocker was in vivo evaluated against A549 xenograft in BALB/c-nu Slc mice, which exhibited 54% tumor growth inhibition through oral administration of 8 mg/kg of body weight and was slightly less active than doxorubicin (68%). In addition, this compound was also profiled for its acute toxicity to ICR mice to afford oral LD50 value of 1,038 mg/kg of body weight.

【 授权许可】

Unknown