Application of Cl3CCONH2/PPh3 towards the Synthesis of Bioactive Amides

Bulletin of the Korean chemical society

Skydow Chaysripongkul¹  Warinthorn Chavasiri¹  Wanchai Pluempanupat¹  Doo Ok Jang¹ 

关键词: Trichloroacetamide;    Triphenylphosphine;    Chlorinating agent;    Amide;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Cl3CCONH2 coupled with PPh3 was determined to be an effective reagent for the conversion of carboxylic acids to their corresponding acid chlorides. Subsequently, these acid chlorides were successfully trapped with amines in the presence of 4-picoline, yielding amides. This practical and efficient protocol can be utilized for the synthesis of biological amides in excellent yields.

【 授权许可】

Unknown