Triphenylphosphine: An efficient catalyst for the synthesis of 4,6-diphenyl-3,4-dihydropyrimidine-2(1H)-thione under thermal conditions

Journal of King Saud University: Science

关键词: 4,6-diphenyl-3,4-dihydropyrimidine-2(1H)-thione;    Triphenylphosphine;    1,3-Diaryl-2-propen-1-one;    Chalcones;   

DOI  :  10.1016/j.jksus.2013.05.004

来源: DOAJ

【 摘 要 】

An efficient and direct procedure for the synthesis of 4,6-diphenyl-3,4-dihydropyrimidine-2(1H)-thione derivatives by condensation of 1,3-diaryl-2-propen-1-ones (chalcones) and thiourea in ethanol at 65 °C using triphenylphosphine (PPh3) as a catalyst is reported. The method gave good yields of 4,6-diphenyl-3,4-dihydropyrimidine-2(1H)-thione derivatives in short reaction times in comparison with earlier methods. The catalyst is recycled without loss of activity. Using non-toxic and inexpensive materials, simple work-up, short reaction times and high yields of the products are the advantages of this method.

【 授权许可】

Unknown