A Novel Deposition Method of PLGA Nanoparticles on Coronary Stents

Bulletin of the Korean chemical society

Hye Yeong Nam¹  Insu Baek¹  So Hee Nam¹  Jae ryang Joo¹  Jong Sang Park¹ 

关键词: PLGA;    Paclitaxel;    Stent;    Nanoparticle deposition;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Bare metal stents which were used to treat coronary artery disease have several biochemical problems. Polymerbased drug-eluting stents (DES) have opened up a new paradigm in the treatment of in-stent restenosis. Many studies and research programmes have proved that DES can prevent restenosis. In our study, paclitaxel-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles have been deposited along the three dimensional scaffold of coronary stents by a method using self-assembling properties of colloidal particles. We found that the nanoparticles were deposited uniformly and closely packed. The amount of paclitaxel was easily controlled by the drug content of the nanoparticles and the deposition count.

【 授权许可】

Unknown