A Convenient Synthesis of Polycyclic ¥ã-Lactams via Pauson-Khand Reaction

Bulletin of the Korean chemical society

Joo Hee Lee¹  Sung Hoon Kim¹  Yong Hoon Kim¹  Hea Jeong Kim¹  Seok Won Kang¹ 

关键词: Polycyclic ¥ã-lactams;    Pauson-Khand reaction;    5;    6;    5 Fused ring systems;    Co2(CO)8;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Pauson-Khand reaction of hydroxyenynes with Co₂(CO)₈ in the presence of N-methylmorpholine N-oxide or trimethylamine N-oxide as a promoter produced polycyclic �?-lactams as single stereoisomers in moderate to excellent yield. These are the first examples of an intramolecular Pauson-Khand reaction on a hydroxyenyne system tethered to a three- and four-membered ring as new skeletons with 5,6,5 fused ring systems.

【 授权许可】

Unknown