Total Synthesis of Licochalcone E

Bulletin of the Korean chemical society

Goo Yoon¹  Zhiguo Liu¹  Hee Jin Jeong¹  Seung Hoon Cheon¹ 

关键词: Licochalcone E;    Aldol condensation;    Claisen rearrangement;    Synthesis;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Total synthesis of (�?)-licochalcone E (1), an allyl retrochalcone isolated from roots of Glycyrrhiza inflata, has been achieved from 4-tetrahydropyranyloxyacetophenone (7) with (E)-2-methoxy-4-(2-methyl-2-butenyloxy)benzaldehyde (6) or (Z)-2-methoxy-4-(2-methyl-2-butenyloxy)-benzaldehyde (11) through a convergent strategy involving aldol condensation and Claisen rearrangement as key steps.

【 授权许可】

Unknown